We wrote once again regarding the ongling criminalization of eight environmental defenders from the community of El Guapinol in Tocoa, Colón Department, who have been imprisoned in “preventive detention” awaiting formal charges since September 2019. A petition for their release was again denied on December 18. To bring attention to several identified environmental, social, human, and economic impacts of large scale mining projects in the Atlantic zone, residents of El Guapinol and surrounding communities (including the eight who are imprisoned) organized the Encampment on the Defense of Water and Life in August 2018. They pointed to contamination of the Guapinol and San Pedro Rivers resulting from an iron ore mine. There are legitimate concerns that the mine is contaminating drinking water sources for populations across three departments in northern Honduras. These eight environmental defenders are: Ewer Alexander Cedillo Cruz, José Abelino Cedillo, Cantarero, José Daniel Márquez Márquez, Kelvin Alejandro Romero Martínez, Porfirio Sorto Cedillo, Orbin Nahúm Hernández, Arnold Javier Alemán, and Jeremías Martínez. Because of the COVID-19 health crisis, their continued imprisonment exposes them to serious risks to their lives. We are therefore urging that authorities in Honduras: 1) immediately release them from preventive detention; 2) condemn the misuse of criminal law to control, neutralize and punish people who exercise the right to organize resistance in defense of land and waterways